When coronary artery disease runs in families, why don't all
family members have it?
All members of the same family do not have the same height or hair
colour, so it makes sense that they will not all have the same
conditions of disease. Genetics and environment both play a role.
Some family members will be exposed to environmental agents that
will trigger disease, and others will not.
How will discoveries about DNA help people and
families with coronary disease?
By discovering the strengths and weakness of someone's genes, we
can personalize medicine based on the prevention, diagnosis,
treatment and prognosis.
Better genetic information may explain why one medication
works better in one person and not in the other. It will make choosing
treatments more precise. If a gene is over-active,
then a scientist can look at ways to turn off or interfere with its
activity. Likewise, if the gene is underactive, scientists can
look at ways to increase its activity. Scientists believe genes will
tell us a lot about the risk of developing coronary artery disease
and the progress of coronary artery disease.
Heart & Stroke Foundation
The Heart Study is partially funded by the Heart & Stroke Foundation, a
national voluntary non-profit organization whose mission is to improve
the health of Canadians by preventing and reducing disability and death
from heart disease and stroke through research, health promotion and advocacy.
Every year, the Heart and Stroke Foundation funds approximately $47 million
of peer-reviewed heart disease and stroke research in Canada. Through its new
strategic Heart and Stroke Foundation Research Fund, the Foundation will invest
$24 million over five years to partner with the Canadian Institutes of
Health Research, and other health research funding agencies to support
innovative research initiatives, like genetic research, aimed at building
linkages across disciplines and advancing knowledge of heart disease and stroke.
Click the logo to find out more about the Heart & Stroke Foundation.